The target is presented to the iscsi address, not an IP specifically. Storage is an HP Lefthand P4500.
I can set up a session after reboot with "nc -z <ip of storage> 3260".
I'm wondering if the upgrade from 4.0 has messed something up internally. When the host came back up, the upgrade had messed up all of the virtual switches and nic bindings. It had configured the management interface on one of the iSCSI ports for example.