I contacted support, if not 5.1 before upgrade then you need to install fresh.
They referred me to installation notes:
You can install the patch over an existing vMA 5.1 installation.
Important: You can install this patch only on vMA 5.1. Use only the Web user interface to upgrade your existing vMA 5.1 instance.
Would have been useful if the Web UI prevented the upgrade if it's not compatiable.